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Agilent offers the largest, most modern liquid chromatography (LC) column portfolios for small molecule analysis, with columns suitable for nearly all separation modes and applications.


Whether you are performing conventional or ultra-fast chromatography, separating biomolecules, or analyzing complex compounds, the industry’s highest-performing compounds deliver fast, reproducible results – all engineered with unparalleled quality and reliability.

Catalog No. Product Net Price
AGIL5190-2416 Agilent Bio MAb, NP10, 4.6 x 50 mm, PEEK. This HPLC column has a densely packed weak cation exchange layer designed for monoclonal antibody separations. The column is PEEK-lined to couple with bio-compatible LC systems. 838 
Add to Cart
  • Inner Diameter (ID)
  • 4.6 mm
  • Length
  • 50 mm
  • Phase
  • WCX
  • UNSPSC Code
  • 41115711
  • Brand
  • Agilent Bio MAb
  • Hardware
  • PEEK
  • LC Platform
  • BioInert
  • Maximum Temperature
  • 80 °C
  • Part Number Application
  • Charge Variant Analysis PeptidesProteinsmAbs
  • Part Number Application Domain
  • Biopharma
  • Particle Size
  • 10 µm
  • Particle Type
  • Non-porous
  • pH Range
  • 2-12
  • Pressure Rating
  • 275 bar
  • Separation Mode
  • Ion Exchange (IEX)
  • Shipping Solvent
  • Phosphate Buffer
  • Technique
  • LC
AGIL5190-2419 Agilent Bio MAb, NP10, 2.1 x 250 mm, PEEK. This HPLC column has a densely packed weak cation exchange layer designed for monoclonal antibody separations. The column is PEEK-lined to couple with bio-compatible LC systems. 1929 
Add to Cart
  • Inner Diameter (ID)
  • 2.1 mm
  • Length
  • 250 mm
  • Phase
  • WCX
  • UNSPSC Code
  • 41115711
  • Brand
  • Agilent Bio MAb
  • Hardware
  • PEEK
  • LC Platform
  • BioInert
  • Maximum Temperature
  • 80 °C
  • Part Number Application
  • Charge Variant Analysis PeptidesProteinsmAbs
  • Part Number Application Domain
  • Biopharma
  • Particle Size
  • 10 µm
  • Particle Type
  • Non-porous
  • pH Range
  • 2-12
  • Pressure Rating
  • 275 bar
  • Separation Mode
  • Ion Exchange (IEX)
  • Shipping Solvent
  • Phosphate Buffer
  • Technique
  • LC
AGIL5190-2420 Agilent Bio MAb, NP10, 2.1 x 50 mm, PEEK. This HPLC column has a densely packed weak cation exchange layer designed for monoclonal antibody separations. The column is PEEK-lined to couple with bio-compatible LC systems. 838 
Add to Cart
  • Inner Diameter (ID)
  • 2.1 mm
  • Length
  • 50 mm
  • Phase
  • WCX
  • UNSPSC Code
  • 41115711
  • Brand
  • Agilent Bio MAb
  • Hardware
  • PEEK
  • LC Platform
  • BioInert
  • Maximum Temperature
  • 80 °C
  • Part Number Application
  • Charge Variant Analysis PeptidesProteinsmAbs
  • Part Number Application Domain
  • Biopharma
  • Particle Size
  • 10 µm
  • Particle Type
  • Non-porous
  • pH Range
  • 2-12
  • Pressure Rating
  • 275 bar
  • Separation Mode
  • Ion Exchange (IEX)
  • Shipping Solvent
  • Phosphate Buffer
  • Technique
  • LC
AGIL5190-6884 Agilent Bio MAb, NP5, 10 x 250 mm, 5 µm. This HPLC column has a densely packed weak cation exchange layer designed for monoclonal antibody separations. The particles are nonporous and promote higher resolution and faster separations. 6732 
Add to Cart
  • Inner Diameter (ID)
  • 10 mm
  • Length
  • 250 mm
  • Phase
  • WCX
  • UNSPSC Code
  • 41115709
  • Brand
  • Agilent Bio MAb
  • Hardware
  • SS
  • LC Platform
  • Preparative HPLC
  • Maximum Temperature
  • 80 °C
  • Part Number Application
  • Charge Variant Analysis PeptidesProteinsmAbs
  • Part Number Application Domain
  • Biopharma
  • Particle Size
  • 5 µm
  • Particle Type
  • Non-porous
  • pH Range
  • 2-12
  • Pressure Rating
  • 413 bar
  • Separation Mode
  • Ion Exchange (IEX)
  • Shipping Solvent
  • Phosphate Buffer
  • Technique
  • LC
AGIL5190-6885 Agilent Bio MAb, NP5, 21.2 x 250 mm, 5 µm. This prep HPLC column has a densely packed weak cation exchange layer designed for monoclonal antibody separations. The particles are nonporous and promote higher resolution and faster separations. 21862 
Add to Cart
  • Inner Diameter (ID)
  • 21.2 mm
  • Length
  • 250 mm
  • Phase
  • WCX
  • UNSPSC Code
  • 41115709
  • Brand
  • Agilent Bio MAb
  • Hardware
  • SS
  • LC Platform
  • Preparative HPLC
  • Maximum Temperature
  • 80 °C
  • Part Number Application
  • Charge Variant Analysis PeptidesProteinsmAbs
  • Part Number Application Domain
  • Biopharma
  • Particle Size
  • 5 µm
  • Particle Type
  • Non-porous
  • pH Range
  • 2-12
  • Pressure Rating
  • 413 bar
  • Separation Mode
  • Ion Exchange (IEX)
  • Shipping Solvent
  • Phosphate Buffer
  • Technique
  • LC
AGIL5190-2501 Agilent Bio SEC-3, 100Å, 7.8 x 300 mm, 3 µm. A size exclusion column for aggregate analysis of peptides and small proteins. Resolving range 0.1-100 kDa. 2635 
Add to Cart
  • Inner Diameter (ID)
  • 7.8 mm
  • Length
  • 300 mm
  • Phase
  • SEC
  • UNSPSC Code
  • 41115711
  • Brand
  • Agilent Bio SEC-3
  • Hardware
  • SS
  • LC Platform
  • Stainless Steel
  • Maximum Temperature
  • 80 °C
  • Molecular Weight Lower Limit
  • 100 Da
  • Part Number Application
  • Aggregate & Fragment Analysis PeptidesProteins
  • Part Number Application Domain
  • Biopharma
  • Particle Size
  • 3 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 2-8.5
  • Pore Size
  • 100 Å
  • Pressure Rating
  • 240 bar
  • Separation Mode
  • Size Exclusion (SEC)
  • Shipping Solvent
  • Phosphate Buffer
  • Technique
  • LC
AGIL5190-2502 Agilent Bio SEC-3, 100Å, 7.8 x 150 mm, 3 µm. A size exclusion column for aggregate analysis of peptides and small proteins. Resolving range 0.1-100 kDa. 2000 
Add to Cart
  • Inner Diameter (ID)
  • 7.8 mm
  • Length
  • 150 mm
  • Phase
  • SEC
  • UNSPSC Code
  • 41115711
  • Brand
  • Agilent Bio SEC-3
  • Hardware
  • SS
  • LC Platform
  • Stainless Steel
  • Maximum Temperature
  • 80 °C
  • Molecular Weight Lower Limit
  • 100 Da
  • Part Number Application
  • Aggregate & Fragment Analysis PeptidesProteins
  • Part Number Application Domain
  • Biopharma
  • Particle Size
  • 3 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 2-8.5
  • Pore Size
  • 100 Å
  • Pressure Rating
  • 240 bar
  • Separation Mode
  • Size Exclusion (SEC)
  • Shipping Solvent
  • Phosphate Buffer
  • Technique
  • LC
AGIL5190-2503 Agilent Bio SEC-3, 100Å, 4.6 x 300 mm, 3 µm. A size exclusion column for aggregate analysis of peptides and small proteins. Resolving range 0.1-100 kDa. 2303 
Add to Cart
  • Inner Diameter (ID)
  • 4.6 mm
  • Length
  • 300 mm
  • Phase
  • SEC
  • UNSPSC Code
  • 41115711
  • Brand
  • Agilent Bio SEC-3
  • Hardware
  • SS
  • LC Platform
  • Stainless Steel
  • Maximum Temperature
  • 80 °C
  • Molecular Weight Lower Limit
  • 100 Da
  • Part Number Application
  • Aggregate & Fragment Analysis PeptidesProteins
  • Part Number Application Domain
  • Biopharma
  • Particle Size
  • 3 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 2-8.5
  • Pore Size
  • 100 Å
  • Pressure Rating
  • 240 bar
  • Separation Mode
  • Size Exclusion (SEC)
  • Shipping Solvent
  • Phosphate Buffer
  • Technique
  • LC
AGIL5190-2504 Agilent Bio SEC-3, 100Å, 4.6 x 150 mm, 3 µm. A size exclusion column for aggregate analysis of peptides and small proteins. Resolving range 0.1-100 kDa. 2039 
Add to Cart
  • Inner Diameter (ID)
  • 4.6 mm
  • Length
  • 150 mm
  • Phase
  • SEC
  • UNSPSC Code
  • 41115711
  • Brand
  • Agilent Bio SEC-3
  • Hardware
  • SS
  • LC Platform
  • Stainless Steel
  • Maximum Temperature
  • 80 °C
  • Molecular Weight Lower Limit
  • 100 Da
  • Part Number Application
  • Aggregate & Fragment Analysis PeptidesProteins
  • Part Number Application Domain
  • Biopharma
  • Particle Size
  • 3 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 2-8.5
  • Pore Size
  • 100 Å
  • Pressure Rating
  • 240 bar
  • Separation Mode
  • Size Exclusion (SEC)
  • Shipping Solvent
  • Phosphate Buffer
  • Technique
  • LC
AGIL5190-2505 Agilent Bio SEC-3, 100Å, 7.8 x 50 mm, 3 µm, guard. A size exclusion guard column to protect and extend the lifetime of a longer analytical SEC column. 863 
Add to Cart
  • Inner Diameter (ID)
  • 7.8 mm
  • Length
  • 50 mm
  • Phase
  • SEC
  • UNSPSC Code
  • 41115711
  • Brand
  • Agilent Bio SEC-3
  • Guard Column
  • Yes
  • Hardware
  • SS
  • LC Platform
  • Stainless Steel
  • Maximum Temperature
  • 80 °C
  • Molecular Weight Lower Limit
  • 100 Da
  • Part Number Application
  • Aggregate & Fragment Analysis PeptidesProteins
  • Part Number Application Domain
  • Biopharma
  • Particle Size
  • 3 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 2-8.5
  • Pore Size
  • 100 Å
  • Pressure Rating
  • 240 bar
  • Separation Mode
  • Size Exclusion (SEC)
  • Shipping Solvent
  • Phosphate Buffer
  • Technique
  • LC

Overview

The small molecule column portfolio includes state-of-the-art superficially porous InfinityLab Poroshell 120 columns as well as traditional fully porous ZORBAX, Polaris, and Pursuit columns.

When you choose Agilent small molecule LC columns, you get more than just a dependable product. You also get unmatched technical support from the world’s largest chromatography supplier.


Agilent gel permeation chromatography (GPC) and size exclusion chromatography (SEC) columns and standards have been the top-selling in the polymer industry for over 40 years. GPC and SEC is used to determine the molecular weight and size distribution of macromolecules. SEC and GPC columns generate accurate, reliable data for critical polymer parameters, including dispersity (PDI), molecular weight mass average (Mw), number average (Mn), and z-average (Mz).


The importance of understanding the attributes of a biologic drug, and the processes used to create it, cannot be underestimated.  Agilent AdvanceBio LC columns are designed and produced to provide results you can be sure of when analyzing highly complex biotherapeutic molecules and monitoring their purity, potency, and other critical quality attributes.



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