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Agilent offers the largest, most modern liquid chromatography (LC) column portfolios for small molecule analysis, with columns suitable for nearly all separation modes and applications.


Whether you are performing conventional or ultra-fast chromatography, separating biomolecules, or analyzing complex compounds, the industry’s highest-performing compounds deliver fast, reproducible results – all engineered with unparalleled quality and reliability.

Catalog No. Product Net Price
AGIL446905-302 Agilent Prep 100Å C18, 30 x 50 mm, 5 µm 3432 
Add to Cart
  • Inner Diameter (ID)
  • 30 mm
  • Length
  • 50 mm
  • Phase
  • C18
  • UNSPSC Code
  • 41115711
  • Brand
  • Agilent Prep
  • Carbon Load
  • 24 %
  • Endcapped
  • Yes
  • Guard Column
  • No
  • Hardware
  • Conventional
  • LC Platform
  • Preparative HPLC
  • Maximum Temperature
  • 40 °C at pH 8-9 60 °C at pH 2-8 40 °C at pH 8-1060 °C at pH 2-8
  • Molecular Weight Lower Limit
  • 0 Da
  • Particle Size
  • 5 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 2-10
  • Pore Size
  • 100 Å
  • Pressure Rating
  • 340 bar
  • Separation Mode
  • Reversed Phase
AGIL446905-902 Agilent Prep-C18 Scalar column, 100Å, 4.6 x 50 mm, 5 µm, 400 bar pressure limit 393 
Add to Cart
  • Inner Diameter (ID)
  • 4.6 mm
  • Length
  • 50 mm
  • Phase
  • Prep-C18
  • UNSPSC Code
  • 41115711
  • Brand
  • Agilent Prep
  • Carbon Load
  • 24 %
  • Endcapped
  • Yes
  • Guard Column
  • No
  • Hardware
  • Conventional
  • LC Platform
  • Preparative HPLC
  • Maximum Temperature
  • 40 °C at pH 8-9 60 °C at pH 2-8 40 °C at pH 8-1060 °C at pH 2-8
  • Molecular Weight Lower Limit
  • 0 Da
  • Particle Size
  • 5 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 2-10
  • Pore Size
  • 100 Å
  • Pressure Rating
  • 400 bar
  • Separation Mode
  • Reversed Phase
  • Shipping Solvent
  • Methanol
AGIL449905-302 Agilent Prep 100Å C18, 30 x 100 mm, 5 µm 4854 
Add to Cart
  • Inner Diameter (ID)
  • 30 mm
  • Length
  • 100 mm
  • Phase
  • C18
  • UNSPSC Code
  • 41115711
  • Brand
  • Agilent Prep
  • Carbon Load
  • 24 %
  • Endcapped
  • Yes
  • Guard Column
  • No
  • Hardware
  • Conventional
  • LC Platform
  • Preparative HPLC
  • Maximum Temperature
  • 40 °C at pH 8-9 60 °C at pH 2-8 40 °C at pH 8-1060 °C at pH 2-8
  • Molecular Weight Lower Limit
  • 0 Da
  • Particle Size
  • 5 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 2-10
  • Pore Size
  • 100 Å
  • Pressure Rating
  • 340 bar
  • Separation Mode
  • Reversed Phase
AGIL449905-502 Agilent Prep 100Å C18, 50 x 100 mm, 5 µm 6052 
Add to Cart
  • Inner Diameter (ID)
  • 50 mm
  • Length
  • 100 mm
  • Phase
  • C18
  • UNSPSC Code
  • 41115711
  • Brand
  • Agilent Prep
  • Carbon Load
  • 24 %
  • Endcapped
  • Yes
  • Guard Column
  • No
  • Hardware
  • Conventional
  • LC Platform
  • Preparative HPLC
  • Maximum Temperature
  • 40 °C at pH 8-9 60 °C at pH 2-8 40 °C at pH 8-1060 °C at pH 2-8
  • Molecular Weight Lower Limit
  • 0 Da
  • Particle Size
  • 5 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 2-10
  • Pore Size
  • 100 Å
  • Pressure Rating
  • 200 bar
  • Separation Mode
  • Reversed Phase
AGIL449905-902 Agilent Prep-C18 Scalar column, 100Å, 4.6 x 100 mm, 5 µm, 400 bar pressure limit 448 
Add to Cart
  • Inner Diameter (ID)
  • 4.6 mm
  • Length
  • 100 mm
  • Phase
  • Prep-C18
  • UNSPSC Code
  • 41115711
  • Brand
  • Agilent Prep
  • Carbon Load
  • 24 %
  • Endcapped
  • Yes
  • Guard Column
  • No
  • Hardware
  • Conventional
  • LC Platform
  • Preparative HPLC
  • Maximum Temperature
  • 40 °C at pH 8-9 60 °C at pH 2-8 40 °C at pH 8-1060 °C at pH 2-8
  • Molecular Weight Lower Limit
  • 0 Da
  • Particle Size
  • 5 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 2-10
  • Pore Size
  • 100 Å
  • Pressure Rating
  • 400 bar
  • Separation Mode
  • Reversed Phase
  • Shipping Solvent
  • Methanol
AGIL449910-902 Agilent Prep-C18 Scalar column, 100Å, 4.6 x 100 mm, 10 µm, 400 bar pressure limit 448 
Add to Cart
  • Inner Diameter (ID)
  • 4.6 mm
  • Length
  • 100 mm
  • Phase
  • Prep-C18
  • UNSPSC Code
  • 41115711
  • Brand
  • Agilent Prep
  • Carbon Load
  • 24 %
  • Endcapped
  • Yes
  • Guard Column
  • No
  • Hardware
  • Conventional
  • LC Platform
  • Preparative HPLC
  • Maximum Temperature
  • 40 °C at pH 8-9 60 °C at pH 2-8 40 °C at pH 8-1060 °C at pH 2-8
  • Molecular Weight Lower Limit
  • 0 Da
  • Particle Size
  • 10 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 2-10
  • Pore Size
  • 100 Å
  • Pressure Rating
  • 400 bar
  • Separation Mode
  • Reversed Phase
  • Shipping Solvent
  • Methanol
AGIL820675-112 ZORBAX Eclipse XDB 80Å C18, 5 µm, 9.4 x 15 mm, guard cartridge (P), use with end-fitting kit 840140-901 247 
Add to Cart
  • Inner Diameter (ID)
  • 9.4 mm
  • Length
  • 15 mm
  • Phase
  • Eclipse XDB-C18
  • UNSPSC Code
  • 41115709
  • USP Designation
  • L1
  • Brand
  • ZORBAX
  • Carbon Load
  • 10 %
  • Endcapped
  • Double
  • Guard Column
  • Yes
  • Hardware
  • Cartridge
  • LC Platform
  • Preparative HPLC
  • Maximum Temperature
  • 40 °C at pH 6-9 60 °C at pH 2-6 40 °C at pH 6-960 °C at pH 2-6
  • Molecular Weight Lower Limit
  • 0 Da
  • Particle Size
  • 5 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 2-9
  • Pore Size
  • 80 Å
  • Pressure Rating
  • 135 bar
  • Separation Mode
  • Reversed Phase
AGIL820675-115 ZORBAX StableBond C8, 7 µm, 9.4 x 15 mm guard cartridge (P), 2/pk 230 
Add to Cart
  • Inner Diameter (ID)
  • 9.4 mm
  • Length
  • 15 mm
  • Phase
  • SB-C8
  • UNSPSC Code
  • 41115711
  • Brand
  • ZORBAX
  • Carbon Load
  • 5.5 %
  • Endcapped
  • No
  • Guard Column
  • Yes
  • Hardware
  • Conventional
  • LC Platform
  • Preparative HPLC
  • Maximum Temperature
  • 40 °C at pH 6-8 80 °C at pH 1-6 40 °C at pH 6-880 °C at pH 1-6
  • Molecular Weight Lower Limit
  • 0 Da
  • Particle Size
  • 7 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 1-8
  • Pore Size
  • 80 Å
  • Pressure Rating
  • 135 bar
  • Separation Mode
  • Reversed Phase
AGIL820675-124 ZORBAX StableBond 300 C3, 9.4 x 15 mm, 7 µm, guard cartridge (P) 2/pk 233 
Add to Cart
  • Inner Diameter (ID)
  • 9.4 mm
  • Length
  • 15 mm
  • Phase
  • 300SB-C3
  • UNSPSC Code
  • 41115711
  • Brand
  • ZORBAX
  • Guard Column
  • Yes
  • Hardware
  • SS
  • LC Platform
  • Stainless Steel
  • Maximum Temperature
  • 80 °C
  • Part Number Application
  • Monoclonal Antibodies (mABs) PeptidesProteins
  • Part Number Application Domain
  • Biopharma
  • Particle Size
  • 7 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 1-8
  • Pore Size
  • 300 Å
  • Pressure Rating
  • 400 bar
  • Separation Mode
  • Reversed Phase
  • Shipping Solvent
  • Acetonitrile/Water
  • Technique
  • LC LC & LC/MS
AGIL880952-202 ZORBAX Original C18, 70Å, 9.4 x 250 mm, 5 µm, 400 bar pressure limit 1601 
Add to Cart
  • Inner Diameter (ID)
  • 9.4 mm
  • Length
  • 250 mm
  • Phase
  • Original C18
  • UNSPSC Code
  • 41115709
  • Brand
  • ZORBAX
  • Carbon Load
  • 20 %
  • Endcapped
  • Yes
  • Guard Column
  • No
  • Hardware
  • Conventional
  • LC Platform
  • HPLC
  • Maximum Temperature
  • 60 °C
  • Molecular Weight Lower Limit
  • 0 Da
  • Particle Size
  • 5 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 2-8
  • Pore Size
  • 70 Å
  • Pressure Rating
  • 400 bar
  • Separation Mode
  • Reversed Phase
  • Shipping Solvent
  • Methanol/Water

Overview

The small molecule column portfolio includes state-of-the-art superficially porous InfinityLab Poroshell 120 columns as well as traditional fully porous ZORBAX, Polaris, and Pursuit columns.

When you choose Agilent small molecule LC columns, you get more than just a dependable product. You also get unmatched technical support from the world’s largest chromatography supplier.


Agilent gel permeation chromatography (GPC) and size exclusion chromatography (SEC) columns and standards have been the top-selling in the polymer industry for over 40 years. GPC and SEC is used to determine the molecular weight and size distribution of macromolecules. SEC and GPC columns generate accurate, reliable data for critical polymer parameters, including dispersity (PDI), molecular weight mass average (Mw), number average (Mn), and z-average (Mz).


The importance of understanding the attributes of a biologic drug, and the processes used to create it, cannot be underestimated.  Agilent AdvanceBio LC columns are designed and produced to provide results you can be sure of when analyzing highly complex biotherapeutic molecules and monitoring their purity, potency, and other critical quality attributes.



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