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Agilent offers the largest, most modern liquid chromatography (LC) column portfolios for small molecule analysis, with columns suitable for nearly all separation modes and applications.


Whether you are performing conventional or ultra-fast chromatography, separating biomolecules, or analyzing complex compounds, the industry’s highest-performing compounds deliver fast, reproducible results – all engineered with unparalleled quality and reliability.

Catalog No. Product Net Price
AGIL799775-904 AdvanceBio RP-mAb C4, 2.1 x 50 mm, 3.5 µm 678 
Add to Cart
  • Inner Diameter (ID)
  • 2.1 mm
  • Length
  • 50 mm
  • Phase
  • C4
  • UNSPSC Code
  • 41115711
  • Brand
  • AdvanceBio RP mAb C4
  • Hardware
  • SS
  • LC Platform
  • Stainless Steel
  • Maximum Temperature
  • 90 °C
  • Part Number Application
  • Aggregate & Fragment AnalysisMonoclonal Antibodies (mABs)PeptidesProteins
  • Part Number Application Domain
  • Biopharma
  • Particle Size
  • 3.5 µm
  • Particle Type
  • Superficially Porous
  • pH Range
  • 1-8
  • Pore Size
  • 450 Å
  • Pressure Rating
  • 600 bar
  • Separation Mode
  • Reversed Phase
  • Shipping Solvent
  • Acetonitrile/Water
  • Technique
  • LC LC & LC/MS
AGIL799775-944 AdvanceBio RP-mAb Diphenyl, 2.1 x 50 mm, 3.5 µm 678 
Add to Cart
  • Inner Diameter (ID)
  • 2.1 mm
  • Length
  • 50 mm
  • Phase
  • Diphenyl
  • UNSPSC Code
  • 41115711
  • Brand
  • AdvanceBio RP mAb Diphenyl
  • Hardware
  • SS
  • LC Platform
  • Stainless Steel
  • Maximum Temperature
  • 90 °C
  • Part Number Application
  • Aggregate & Fragment AnalysisMonoclonal Antibodies (mABs)PeptidesProteins
  • Part Number Application Domain
  • Biopharma
  • Particle Size
  • 3.5 µm
  • Particle Type
  • Superficially Porous
  • pH Range
  • 1-8
  • Pore Size
  • 450 Å
  • Pressure Rating
  • 600 bar
  • Separation Mode
  • Reversed Phase
  • Shipping Solvent
  • Acetonitrile/Water
  • Technique
  • LC LC & LC/MS
AGIL799975-904 AdvanceBio RP-mAb C4, 4.6 x 50 mm, 3.5 µm 675 
Add to Cart
  • Inner Diameter (ID)
  • 4.6 mm
  • Length
  • 50 mm
  • Phase
  • C4
  • UNSPSC Code
  • 41115711
  • Brand
  • AdvanceBio RP mAb C4
  • Hardware
  • SS
  • LC Platform
  • Stainless Steel
  • Maximum Temperature
  • 90 °C
  • Part Number Application
  • Aggregate & Fragment AnalysisMonoclonal Antibodies (mABs)PeptidesProteins
  • Part Number Application Domain
  • Biopharma
  • Particle Size
  • 3.5 µm
  • Particle Type
  • Superficially Porous
  • pH Range
  • 1-8
  • Pore Size
  • 450 Å
  • Pressure Rating
  • 600 bar
  • Separation Mode
  • Reversed Phase
  • Shipping Solvent
  • Acetonitrile/Water
  • Technique
  • LC LC & LC/MS
AGIL799975-944 AdvanceBio RP-mAb Diphenyl, 4.6 x 50 mm, 3.5 µm 675 
Add to Cart
  • Inner Diameter (ID)
  • 4.6 mm
  • Length
  • 50 mm
  • Phase
  • Diphenyl
  • UNSPSC Code
  • 41115711
  • Brand
  • AdvanceBio RP mAb Diphenyl
  • Hardware
  • SS
  • LC Platform
  • Stainless Steel
  • Maximum Temperature
  • 90 °C
  • Part Number Application
  • Aggregate & Fragment AnalysisMonoclonal Antibodies (mABs)PeptidesProteins
  • Part Number Application Domain
  • Biopharma
  • Particle Size
  • 3.5 µm
  • Particle Type
  • Superficially Porous
  • pH Range
  • 1-8
  • Pore Size
  • 450 Å
  • Pressure Rating
  • 600 bar
  • Separation Mode
  • Reversed Phase
  • Shipping Solvent
  • Acetonitrile/Water
  • Technique
  • LC LC & LC/MS
PL1580-3250 AdvanceBio SEC 120 Å column, 1.9 µm, 4.6 x 150 mm. A size exclusion column designed to improve resolution and provide faster separation of protein and peptide aggregates and fragments by UHPLC. Resolving range is 1-80 kDa. 2339 
Add to Cart
  • Inner Diameter (ID)
  • 4.6 mm
  • Length
  • 150 mm
  • Phase
  • SEC
  • UNSPSC Code
  • 41115709
  • Brand
  • AdvanceBio SEC
  • Guard Column
  • No
  • Hardware
  • SS
  • LC Platform
  • Stainless Steel
  • Maximum Temperature
  • 80 °C
  • Molecular Weight Lower Limit
  • 1000 Da
  • Particle Size
  • 1.9 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 2-8.5
  • Pore Size
  • 120 Å
  • Pressure Rating
  • 620 bar
  • Separation Mode
  • Size Exclusion (SEC)
  • Shipping Solvent
  • Phosphate Buffer/0.02% Sodium azide
  • Technique
  • LC
PL1980-1201PK AdvanceBio SEC 200A 1.9um 2.1x50mm PEEK. A size exclusion column designed for higher resolution and faster separation of protein aggregates and fragments by UHPLC. PEEK-lined stainless steel hardware offers a metal-free sample flow path. 1672 
Add to Cart
  • Inner Diameter (ID)
  • 2.1 mm
  • Length
  • 50 mm
  • Phase
  • SEC
  • Brand
  • AdvanceBio SEC
  • Guard Column
  • No
  • Hardware
  • PEEK Lined SS
  • LC Platform
  • BioInert
  • Maximum Temperature
  • 80 °C (20 to 40 °C recommended)
  • Molecular Weight Lower Limit
  • 2000 Da
  • Particle Size
  • 1.9 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 2-8.5
  • Pore Size
  • 200 Å
  • Pressure Rating
  • 620 bar
  • Separation Mode
  • Size Exclusion (SEC)
  • Shipping Solvent
  • Phosphate Buffer/0.02% Sodium azide
  • Technique
  • LC & LC/MS
PL1980-1250PK AdvanceBio SEC 120A 1.9um 2.1x50mm PEEK. A size exclusion column designed for higher resolution and faster separation of protein and peptide aggregates and fragments. PEEK-lined stainless steel hardware offers a metal-free sample flow path. 1672 
Add to Cart
  • Inner Diameter (ID)
  • 2.1 mm
  • Length
  • 50 mm
  • Phase
  • SEC
  • Brand
  • AdvanceBio SEC
  • Guard Column
  • No
  • Hardware
  • PEEK Lined SS
  • LC Platform
  • BioInert
  • Maximum Temperature
  • 80 °C (20 to 40 °C recommended)
  • Molecular Weight Lower Limit
  • 1000 Da
  • Particle Size
  • 1.9 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 2-8.5
  • Pore Size
  • 120 Å
  • Pressure Rating
  • 620 bar
  • Separation Mode
  • Size Exclusion (SEC)
  • Shipping Solvent
  • Phosphate Buffer/0.02% Sodium azide
  • Technique
  • LC & LC/MS
PL1980-3201PK AdvanceBio SEC 200A 1.9um 2.1x150mm PEEK. A size exclusion column designed for higher resolution and faster separation of protein aggregates and fragments by UHPLC. PEEK-lined stainless steel hardware offers a metal-free sample flow path. 1809 
Add to Cart
  • Inner Diameter (ID)
  • 2.1 mm
  • Length
  • 150 mm
  • Phase
  • SEC
  • Brand
  • AdvanceBio SEC
  • Guard Column
  • No
  • Hardware
  • PEEK Lined SS
  • LC Platform
  • BioInert
  • Maximum Temperature
  • 80 °C (20 to 40 °C recommended)
  • Molecular Weight Lower Limit
  • 2000 Da
  • Particle Size
  • 1.9 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 2-8.5
  • Pore Size
  • 200 Å
  • Pressure Rating
  • 620 bar
  • Separation Mode
  • Size Exclusion (SEC)
  • Shipping Solvent
  • Phosphate Buffer/0.02% Sodium azide
  • Technique
  • LC & LC/MS
PL1980-3250PK AdvanceBio SEC 120A 1.9um 2.1x150mm PEEK. A size exclusion column designed for higher resolution and faster separation of protein and peptide aggregates and fragments. PEEK-lined stainless steel hardware offers a metal-free sample flow path. 1809 
Add to Cart
  • Inner Diameter (ID)
  • 2.1 mm
  • Length
  • 150 mm
  • Phase
  • SEC
  • Brand
  • AdvanceBio SEC
  • Guard Column
  • No
  • Hardware
  • PEEK Lined SS
  • LC Platform
  • BioInert
  • Maximum Temperature
  • 80 °C (20 to 40 °C recommended)
  • Molecular Weight Lower Limit
  • 1000 Da
  • Particle Size
  • 1.9 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 2-8.5
  • Pore Size
  • 120 Å
  • Pressure Rating
  • 620 bar
  • Separation Mode
  • Size Exclusion (SEC)
  • Shipping Solvent
  • Phosphate Buffer/0.02% Sodium azide
  • Technique
  • LC & LC/MS
PL1180-1301 AdvanceBio SEC 300Å, 7.8 x 50 mm, 2.7 µm, LC guard column. to protect and extend the lifetime of a longer analytical SEC column. 669 
Add to Cart
  • Inner Diameter (ID)
  • 7.8 mm
  • Length
  • 50 mm
  • Phase
  • SEC
  • UNSPSC Code
  • 41115711
  • Brand
  • AdvanceBio SEC
  • Guard Column
  • Yes
  • Hardware
  • SS
  • LC Platform
  • Stainless Steel
  • Maximum Temperature
  • 80 °C
  • Molecular Weight Lower Limit
  • 5000 Da
  • Part Number Application
  • Aggregate & Fragment AnalysisMonoclonal Antibodies (mABs)PeptidesProteins
  • Part Number Application Domain
  • Biopharma
  • Particle Size
  • 2.7 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 2-8.5
  • Pore Size
  • 300 Å
  • Pressure Rating
  • 400 bar
  • Separation Mode
  • Size Exclusion (SEC)
  • Shipping Solvent
  • 0.02% Sodium azide
  • Technique
  • LC

Overview

The small molecule column portfolio includes state-of-the-art superficially porous InfinityLab Poroshell 120 columns as well as traditional fully porous ZORBAX, Polaris, and Pursuit columns.

When you choose Agilent small molecule LC columns, you get more than just a dependable product. You also get unmatched technical support from the world’s largest chromatography supplier.


Agilent gel permeation chromatography (GPC) and size exclusion chromatography (SEC) columns and standards have been the top-selling in the polymer industry for over 40 years. GPC and SEC is used to determine the molecular weight and size distribution of macromolecules. SEC and GPC columns generate accurate, reliable data for critical polymer parameters, including dispersity (PDI), molecular weight mass average (Mw), number average (Mn), and z-average (Mz).


The importance of understanding the attributes of a biologic drug, and the processes used to create it, cannot be underestimated.  Agilent AdvanceBio LC columns are designed and produced to provide results you can be sure of when analyzing highly complex biotherapeutic molecules and monitoring their purity, potency, and other critical quality attributes.



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