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Catalog No. CYT17548202
Part No. 17548202
Supplier Cytiva
LambdaFabSelect, 200 mL
Net Price
9939
Availability

4 weeks

PROPERTIES
  • Chromatography technique
    Antibody affinity chromatography
  • Pack size
    25 mL
  • Order Information
    This product is part of our Custom Designed Media program and not yet a standard product. If you are interested in large-scale quantities, please contact your local Cytiva representative.
  • Chemical stability
    Stable to commonly used aqueous buffers: 6 M urea, 6 M guanidine hydrochloride, 70 % ethanol, 30 % isopropanol
  • Storage
    2 to 8°C, 20% Ethanol
  • BioProcess resin
    No
  • Ligand
    Recombinant protein (Mr 13 000), produced in S. cerevisiae, with affinity for the constant domain of the immunoglobulin lambda light chain
  • Matrix
    Highly cross-linked agarose
  • Pressure/Flow Specification
    300 kPa at 600 cm/h, 1 m diameter column, 20 cm bed height
  • pH stability, CIP
    2–12
  • pH stability, operational
    3–10
  • Binding Capacity/ml Chromatography Medium
    Approximately 20 mg Fab/mL of resin
DESCRIPTION
LambdaFabSelect is an affinity resin designed for the purification of human lambda Fab fragments, with high binding capacity, purity, and yield. Rigid agarose base matrix allows high flow rates and processing of large sample volumes for increased throughput Non-mammalian derived product reduces regulatory concerns in the production of Fabs for clinical applications LambdaFabSelect is an affinity resin designed for the purification of human lambda Fab fragments. The ligand binds to the constant region of the light chain enabling an efficient capture step for human antibody fragments such as Fabs with high purity and yield. Antibody fragments, especially Fabs, are getting increased attention as potential biopharmaceuticals because they have some advantages over monoclonal antibodies (Mabs). For example, Fabs show improved pharmacokinetics for tissue penetration and can bind to targets inaccessible to conventional antigen-binding sites.The product is a part of Cytiva's Custom Designed resins program.
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