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Agilent offers the largest, most modern liquid chromatography (LC) column portfolios for small molecule analysis, with columns suitable for nearly all separation modes and applications.


Whether you are performing conventional or ultra-fast chromatography, separating biomolecules, or analyzing complex compounds, the industry’s highest-performing compounds deliver fast, reproducible results – all engineered with unparalleled quality and reliability.

Catalog No. Product Net Price
PL1312-1301 PLRP-S 300Å, 1.0 x 50 mm, 3 µm 638 
Add to Cart
  • Inner Diameter (ID)
  • 1 mm
  • Length
  • 50 mm
  • Phase
  • DVB
  • UNSPSC Code
  • 41115711
  • Brand
  • PLRP-S
  • Hardware
  • SS
  • LC Platform
  • Stainless Steel
  • Maximum Temperature
  • 200 °C
  • Part Number Application
  • Peptides Preparative HPLC Columns & Bulk MediaProteins
  • Part Number Application Domain
  • Biopharma
  • Particle Size
  • 3 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 1-14
  • Pore Size
  • 300 Å
  • Pressure Rating
  • 275 bar
  • Separation Mode
  • Reversed Phase
  • Shipping Solvent
  • Acetonitrile/Water
  • Technique
  • LC LC & LC/MS
PL1312-1500 PLRP-S 100Å, 1.0 x 50 mm, 5 µm 572 
Add to Cart
  • Inner Diameter (ID)
  • 1 mm
  • Length
  • 50 mm
  • Phase
  • DVB
  • UNSPSC Code
  • 41115711
  • Brand
  • PLRP-S
  • Hardware
  • SS
  • LC Platform
  • Stainless Steel
  • Maximum Temperature
  • 200 °C
  • Part Number Application
  • Peptides Preparative HPLC Columns & Bulk MediaProteins
  • Part Number Application Domain
  • Biopharma
  • Particle Size
  • 5 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 1-14
  • Pore Size
  • 100 Å
  • Pressure Rating
  • 207 bar
  • Separation Mode
  • Reversed Phase
  • Shipping Solvent
  • Acetonitrile/Water
  • Technique
  • LC LC & LC/MS
PL1312-1501 PLRP-S 300Å, 1.0 x 50 mm, 5 µm 665 
Add to Cart
  • Inner Diameter (ID)
  • 1 mm
  • Length
  • 50 mm
  • Phase
  • DVB
  • UNSPSC Code
  • 41115711
  • Brand
  • PLRP-S
  • Hardware
  • SS
  • LC Platform
  • Stainless Steel
  • Maximum Temperature
  • 200 °C
  • Part Number Application
  • Peptides Preparative HPLC Columns & Bulk MediaProteins
  • Part Number Application Domain
  • Biopharma
  • Particle Size
  • 5 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 1-14
  • Pore Size
  • 300 Å
  • Pressure Rating
  • 207 bar
  • Separation Mode
  • Reversed Phase
  • Shipping Solvent
  • Acetonitrile/Water
  • Technique
  • LC LC & LC/MS
PL1312-1803 PLRP-S 4000Å, 1.0 x 50 mm, 8 µm 625 
Add to Cart
  • Inner Diameter (ID)
  • 1 mm
  • Length
  • 50 mm
  • Phase
  • DVB
  • UNSPSC Code
  • 41115711
  • Brand
  • PLRP-S
  • Hardware
  • SS
  • LC Platform
  • Stainless Steel
  • Maximum Temperature
  • 200 °C
  • Part Number Application
  • Peptides Preparative HPLC Columns & Bulk MediaProteins
  • Part Number Application Domain
  • Biopharma
  • Particle Size
  • 8 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 1-14
  • Pore Size
  • 4000 Å
  • Pressure Rating
  • 207 bar
  • Separation Mode
  • Reversed Phase
  • Shipping Solvent
  • Acetonitrile/Water
  • Technique
  • LC LC & LC/MS
AGIL588915-902 HC-C18(2), 170Å, 4.6 x 150 mm, 5 µm, 400 bar pressure limit 349 
Add to Cart
  • Inner Diameter (ID)
  • 4.6 mm
  • Length
  • 150 mm
  • Phase
  • C18
  • UNSPSC Code
  • 41115709
  • Brand
  • HC(2)/TC(2)
  • Carbon Load
  • 17 %
  • Endcapped
  • Yes
  • Guard Column
  • No
  • Hardware
  • Conventional
  • LC Platform
  • HPLC
  • Maximum Temperature
  • 60 °C
  • Molecular Weight Lower Limit
  • 0 Da
  • Particle Size
  • 5 µm
  • Particle Type
  • Fully Porous
  • pH Range
  • 2-9
  • Pore Size
  • 170 Å
  • Pressure Rating
  • 400 bar
  • Separation Mode
  • Reversed Phase
AGIL820750-905 AdvanceBio Glycan Mapping 120Å, 4.6 x 5 mm, 2.7 µm, guard, 3/pk. A superficially porous particle with amide HILIC chemistry. 664 
Add to Cart
  • Inner Diameter (ID)
  • 4.6 mm
  • Length
  • 5 mm
  • Phase
  • Amide HILIC
  • UNSPSC Code
  • 41115711
  • Brand
  • AdvanceBio Glycan Mapping
  • Guard Column
  • Yes
  • Hardware
  • SS
  • LC Platform
  • Stainless Steel
  • Maximum Temperature
  • 40 °C
  • Part Number Application
  • Glycan Analysis
  • Part Number Application Domain
  • Biopharma
  • Particle Size
  • 2.7 µm
  • Particle Type
  • Superficially Porous
  • pH Range
  • 2-7
  • Pore Size
  • 120 Å
  • Pressure Rating
  • 600 bar
  • Separation Mode
  • HILIC
  • Shipping Solvent
  • Acetonitrile/Water
  • Technique
  • LC & LC/MS
AGIL821725-906 AdvanceBio Glycan Mapping 120Å, 2.1 x 5 mm, 2.7 µm, guard, 3/pk. These guard columns have superficially porous particles with amide HILIC chemistry. Pair with an analytical column of the same phase to protect and extend the lifetime of the analytical col 664 
Add to Cart
  • Inner Diameter (ID)
  • 2.1 mm
  • Length
  • 5 mm
  • Phase
  • Amide HILIC
  • UNSPSC Code
  • 41115711
  • Brand
  • AdvanceBio Glycan Mapping
  • Guard Column
  • Yes
  • Hardware
  • SS
  • LC Platform
  • Stainless Steel
  • Maximum Temperature
  • 40 °C
  • Part Number Application
  • Glycan Analysis
  • Part Number Application Domain
  • Biopharma
  • Particle Size
  • 2.7 µm
  • Particle Type
  • Superficially Porous
  • pH Range
  • 2-7
  • Pore Size
  • 120 Å
  • Pressure Rating
  • 600 bar
  • Separation Mode
  • HILIC
  • Shipping Solvent
  • Acetonitrile/Water
  • Technique
  • LC & LC/MS
AGIL820750-911 InfinityLab Poroshell 120 EC-C18, 4.6 x 5 mm, 2.7 µm, guard column, 3/pk 560 
Add to Cart
  • Inner Diameter (ID)
  • 4.6 mm
  • Length
  • 5 mm
  • Phase
  • EC-C18
  • UNSPSC Code
  • 41115711
  • Brand
  • InfinityLab Poroshell 120
  • Carbon Load
  • 10 %
  • Endcapped
  • Yes
  • Guard Column
  • Yes
  • Hardware
  • Conventional
  • LC Platform
  • HPLC UHPLC
  • Maximum Temperature
  • 40 °C at pH 6-9 60 °C at pH 2-6 40 °C at pH 6-860 °C at pH 2-6
  • Molecular Weight Lower Limit
  • 0 Da
  • Particle Size
  • 2.7 µm
  • Particle Type
  • Superficially Porous
  • pH Range
  • 2-8
  • Pore Size
  • 120 Å
  • Pressure Rating
  • 600 bar
  • Separation Mode
  • Reversed Phase
  • Shipping Solvent
  • Acetonitrile/Water
AGIL820750-912 InfinityLab Poroshell 120 Stablebond C18, 4.6 x 5 mm, 2.7 µm, UHPLC guard, 3/pk 560 
Add to Cart
  • Inner Diameter (ID)
  • 4.6 mm
  • Length
  • 5 mm
  • Phase
  • SB-C18
  • UNSPSC Code
  • 41115711
  • USP Designation
  • L1
  • Brand
  • InfinityLab Poroshell 120
  • Carbon Load
  • 8 %
  • Endcapped
  • No
  • Guard Column
  • Yes
  • Hardware
  • Conventional
  • LC Platform
  • HPLC UHPLC
  • Maximum Temperature
  • 40 °C at pH 6-8 80 °C at pH 1-6 40 °C at pH 6-880 °C at pH 1-6
  • Molecular Weight Lower Limit
  • 0 Da
  • Particle Size
  • 2.7 µm
  • Particle Type
  • Superficially Porous
  • pH Range
  • 1-8
  • Pore Size
  • 120 Å
  • Pressure Rating
  • 600 bar
  • Separation Mode
  • Reversed Phase
AGIL820750-913 InfinityLab Poroshell 120 EC-C8, 4.6 x 5 mm, 2.7 µm, guard column, 3/pk 560 
Add to Cart
  • Inner Diameter (ID)
  • 4.6 mm
  • Length
  • 5 mm
  • Phase
  • EC-C8
  • UNSPSC Code
  • 41115709
  • USP Designation
  • L7
  • Brand
  • InfinityLab Poroshell 120
  • Carbon Load
  • 5 %
  • Endcapped
  • Yes
  • Guard Column
  • Yes
  • Hardware
  • Conventional
  • LC Platform
  • HPLC UHPLC
  • Maximum Temperature
  • 60 °C
  • Molecular Weight Lower Limit
  • 0 Da
  • Particle Size
  • 2.7 µm
  • Particle Type
  • Superficially Porous
  • pH Range
  • 2-9
  • Pore Size
  • 120 Å
  • Pressure Rating
  • 600 bar
  • Separation Mode
  • Reversed Phase

Overview

The small molecule column portfolio includes state-of-the-art superficially porous InfinityLab Poroshell 120 columns as well as traditional fully porous ZORBAX, Polaris, and Pursuit columns.

When you choose Agilent small molecule LC columns, you get more than just a dependable product. You also get unmatched technical support from the world’s largest chromatography supplier.


Agilent gel permeation chromatography (GPC) and size exclusion chromatography (SEC) columns and standards have been the top-selling in the polymer industry for over 40 years. GPC and SEC is used to determine the molecular weight and size distribution of macromolecules. SEC and GPC columns generate accurate, reliable data for critical polymer parameters, including dispersity (PDI), molecular weight mass average (Mw), number average (Mn), and z-average (Mz).


The importance of understanding the attributes of a biologic drug, and the processes used to create it, cannot be underestimated.  Agilent AdvanceBio LC columns are designed and produced to provide results you can be sure of when analyzing highly complex biotherapeutic molecules and monitoring their purity, potency, and other critical quality attributes.



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