DESCRIPTION
ChromegaChiral™ CCA F4 is a tris(4-Fluoro 3-methylphenylcarbamate) amylose phase which can be used in SFC or HPLC. ChromegaChiral CCA F4 incorporates a fluoro group in its structure. The addition of a fluorine atom into a phenyl carbamate amylose structure can be useful in promoting fluorophilic retention mechanism which can provide improved retention for fluorinated compounds. A fluorophilic retention mechanism can be particularly useful in medicinal chemistry and drug discovery, where more than a third of newly approved small molecule drugs contain fluorine.
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