LiChrospher® RP-select B is a versatile traditionally produced spherical silica gel carriers with reversed phase properties and with the hydrophobicity of a C-8 phase. This carrier is very well suited for the separation of basic compounds, but with still good properties for the determination of neutral and acidic compounds. This sorbent is packed into a Hibar® 100-4.6 HPLC column. For mounting of a LiChroCART® 4-4 guard column, the guard column holder 1.51487 has to be used.