Sephacryl™ High Resolution size exclusion chromatography resins allow fast and reproducible purification of proteins, polysaccharides, and other macromolecules by size exclusion chromatography at laboratory and industrial scale. Cost-efficient gel filtration resins providing high resolution with fast and easy operation. Five different fractionation ranges available in Sephacryl™ HR family allows for reproducible separations over a wide molecular weight range. Sephacryl™ S-200 High Resolution resin is designed for purifying antibodies, serum proteins and mid-size proteins (fractionation range globular proteins 5 × 10³ – 2.5 × 10⁵). BioProcess™ resin supported for industrial applications and well-established in approved processes. Sephacryl™ High Resolution chromatography resins is a highly versatile gel filtration resins that offers a wide range of fractionation capabilities. The matrix of Sephacryl™ High Resolution resins is a cross-linked copolymer of allyl dextran and N,N’-methylene bisacrylamide. This crosslinking gives good rigidity and chemical stability. The narrow particle size distribution, together with steep selectivity curves, results in good preparative characteristics with maintained high resolution. The hydrophilic nature of the resins minimizes nonspecific adsorption and maximizes recovery. The excellent resolution and flow characteristics, long-term physical and chemical stability, and ease of handling make Sephacryl™ HR the resin of choice for routine purification. Sephacryl™ High Resolution is available in a range of different bulk pack sizes and convenient pre-packed formats for easy scale-up and process development. As a BioProcess™ resin Sephacryl™ High Resolution meets industrial demands with security of supply and comprehensive technical and regulatory support Sephacryl™ S-100 High Resolution is designed for separating peptides and small proteins (fractionation range globular proteins 1 × 10³–1 × 10⁵). Sephacryl™ S-200 High Resolution are for purifying antibodies, serum proteins and mid-size proteins (fractionation range globular proteins 5 × 10³–2.5 × 10⁵). Sephacryl™ S-300 High Resolution are for purifying antibodies, serum proteins and mid-size proteins (fractionation range globular proteins 1 × 10⁴–1.5 × 10⁶). Sephacryl™ S-400 High Resolution to separate polysaccharides, macromolecules with extended structures and even small particles such as plasmids. (fractionation range globular proteins 2 × 10⁴–8 × 10⁶). Sephacryl™ S-500 High Resolution to separate polysaccharides, macromolecules with extended structures and even small particles such as plasmids (fractionation range Dextrans 4 × 10⁴–2 × 10⁷)