DESCRIPTION
ChromegaChiral™ CCO F4 T3 (tris(4-Fluoro-3-(trifluoromethylphenyl carbamate) cellulose) incorporates fluoro groups into its structure, and can be used in SFC or HPLC. The addition of a fluorine atom into a phenyl cellulose structure can be useful in promoting fluorophilic retention mechanism which can provide improved retention for fluorinated compounds. A fluorophilic retention mechanism can be particular useful in medicinal chemistry and drug discovery, where more than a third of newly approved small molecule drugs contain fluorine.
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