Capto™ Butyl-S is a hydrophobic interaction chromatography resin designed for the capture and intermediate stages of protein purification. It is the least hydrophobic resin in the range of high-productivity Capto™ HIC resins. High-productivity resin designed for the binding and elution of relatively strong hydrophobic molecules at comparatively low salt concentrations Improved productivity and process economy in downstream operations compared with predecessor Butyl-S Sepharose™ resin Excellent chemical stability The least hydrophobic resin in the range of high-productivity Capto™ HIC resins Low risk of denaturation of relatively strong hydrophobic solutes Capto™ Butyl-S high-productivity HIC resin Capto™ Butyl-S is a custom-designed resin developed for large-scale purification of mAbs, mAb variants, and other biomolecules. It is the least hydrophobic resin in the range of high-productivity Capto™ HIC resins. This resin is designed for the binding and elution of relatively strong hydrophobic molecules at comparatively low salt concentrations. It is particularly useful during the initial stages of a separation process to remove the bulk of impurities without stringent requirements for conditioning of the sample (e.g., adjustment of pH, salt concentration, etc.). It is a BioProcess™ resin that meets the demands of large-scale biopharmaceutical manufacturers for efficient and cost-effective protein purification. The resin includes validated manufacturing methods, secured supply, and Regulatory Support File (RSF) to assist process validation and submission to regulatory authorities. Other Capto™ HIC resins We offer other Capto™ resins for hydrophobic interaction chromatography with different hydrophobicities (Fig 1). High-flow and high-capacity HIC resins: Capto™ Phenyl resin Capto™ Butyl resin Capto™ Octyl resin High-resolution HIC resins: Capto™ Phenyl ImPres resin Capto™ Butyl ImpRes resin See an overview of our HIC resins.