With high flow and capacity, broad fluid compatibility, and low protein adsorption, AcroPak™ 200 capsules with Supor™ membrane, a Pall Life Sciences product, are best suited for filtration of preparative fluids such as buffers, media, and bioprocess intermediates. Efficient Processing of Liquid Volumes Up To 20 L Supor™ membrane has high flow rates and throughputs, and is ideal for solutions where low protein binding is required. Not recommended for use with some ketones. Built-in prefilter extends filter life when particulate-laden solutions, such as serum-containing media, are processed. Upstream vent prevents vapor lock. Manufactured without the use of adhesives to minimize extractables. Sterilization by gamma irradiation eliminates potential contamination by EtO residuals. Materials of Construction Filter Media: Supor™[hydrophilic polyethersulfone (PES)] membrane Housing, Vent Plug, and Support Material: Polypropylene Sealing Technology: Thermal bonding Filling Bell: Polycarbonate Pore Size 0.8/0.2 μm Effective Filtration Area 200 cm2Dimensions (Nominal) Overall Length: 10.5 cm (4.1 in.) Housing Diameter With Vent: 6.7 cm (2.6 in.) Housing Diameter Without Vent: 5.3 cm (2.1 in.) Inlet/Outlet Connections 6.4 - 12.7 mm (1/4 - 1/2 in.) stepped hose barb with filling bell on outlet Typical Hold-Up Volume (with 10 psi air purge) ≤ 6 mL Maximum Operating Temperature 60°C (140°F) at 2.1 bar (210 kPa, 30 psi) Maximum Operating Pressure 4.1 bar (410 kPa, 60 psi) at ambient temperature Recommended Integrity Test Minimum Bubble Point – Water 3.5 bar (350 kPa, 51 psi) Typical Water Flow Rate (1 cp) mL/min at 0.1 bar (10 kPa): 300 mL/min/psi: 207 Bacterial Retention Lot samples retain a minimum 107 cfu/cm2 of B. diminuta per modified ASTM F838, current revision Endotoxin Level Biological Safety Passes United States Pharmacopeia (USP) Biological Reactivity Test, In Vivo Sterilization Capsules that have been sterilized by gamma radiation can be autoclaved for 1 x 1/2hr cycle at 125°C Applications Small- to medium-volume sterile filtration Suitable for use with fluids containing dilute proteins, preservatives, or other critical components Sterile filtration of media and buffers Point-of-use filtration for laboratory water