DESCRIPTION
Pegasus™ SV4 membrane in Mini Kleenpak™ capsules, a Pall Life Sciences product, provide constant, stable flow rate-performance filters for precise, economical scale-up in virus filter process development.
With the ever-present risk of virus contamination in biologic products, potential sources of virus contamination of biotechnology products include viruses associated with cell lines (endogenous viruses), or viruses introduced into the cell line or product from culture medium or during the production process (adventitious viruses). Viruses could also potentially be present in donations for plasma derivatives.
The Mini Kleenpak Capsule Filterability Tool with Pegasus SV4 virus removal filter membrane is designed for quick and efficient filter sizing studies using small fluid volumes either following, or instead of bench scale flat disc trials. Studies performed using this device predict filtration area requirements of Pegasus SV4 membrane in larger, AB-style filter cartridges or Kleenpak Nova filter capsules. These full-process scale formats utilize a laid-over-pleat membrane construction to maximize available filtration area per filter element (2.25 m² per 254 mm [10 inch] module). Consult the relevant product datasheets USD2847 Pegasus SV4 Virus Removal Filter Cartridges, and USD2856 for Kleenpak Nova Filter Capsules with Pegasus SV4 Virus Removal Filter Membrane.
Mini Kleenpak capsules are used in the laboratory for process development and in pilot and manufacturing scale operations if processing requirements do not demand a large filter (process volumes from 2 L to 50 L). These filters are excellent for modeling filter performance at large production scale
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